THC acts as a partial agonist at cannabinoid receptors (CB1 and CB2) (Pertwee, 2008). A very high binding affinity of THC with the CB1 receptor appears to mediate its psychoactive properties (changes in mood or consciousness), memory processing, motor control, etc.Nov 13, 2018
Anandamide is a neurotransmitter that binds to cannabinoid receptors in the brain and body, stimulating a sense of happiness and mental wellness. Anandamide is a little-known brain chemical that's been called the “bliss molecule” for the role it plays in producing feelings of happiness.Sep 1, 2021
Anandamide synthesis is initiated by intracellular Ca2+ rises and/or by activation of G-protein-coupled receptors. For example, activation of vanilloid receptors elevates intracellular Ca2+ levels and stimulates anandamide synthesis in rat sensory neurons in culture.
Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide.
Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world.